COMPARISON OF THERAPIES BASED ON CARVEDILOL AND METOPROLOL IN HYPERTENSIVE PATIENTS WITH OVERWEIGHT OR OBESITY. THE FIRST RESULTS OF CAMELLIA TRIAL
https://doi.org/10.20996/1819-6446-2009-5-1-23-27
Abstract
Aim. To evaluate antihypertensive and metabolic effects of the therapy based on carvedilol (C) in comparison with metoprolol (M) in hypertensive patients with overweight or obesity.
Material and methods. 320 patients were involved in multicenter, randomized open parallel study. One part of the patients received C 12,5 mg BID (Vedicardol, “Sintez”), another part – M 25 mg/day BID. Doubling dose of β-blockers (BB) and switching patients to combined therapy with AML 5-10 mg OD (Amlorus, “Sintez”) and hydrochlorothiazide (HCT) 12,5-25 mg OD was performed if necessary. The study duration was 24 weeks.
Results. Significant reduction of systolic and diastolic blood pressure was revealed in both groups, there was no difference between groups (р=0,88 and p=0,61 respectively). Switching patients to combined therapy with AML and HCT was made more often in M group than in C group (p>0,05). Prescription of BB resulted in significant reduction of the heart rate, there was no difference between groups (p=0,61). 96,2% patients of group C and 95,5% of group M reached target levels of BP. Significant reduction of glucose (p<0,01) and uric acid levels were registered in group C as well as tendency to lowering of total cholesterol (TC) and low density lipoprotein cholesterol (LDLC) levels. 34 adverse effects were registered during observation period: 24 in group C and 10 in group M (p>0.05), half of them were not related to BB taking.
Conclusion: Controlled antihypertensive therapy, based on С and M, allows reaching target levels of BP in majority of patients with overweight or obesity. Switching to combined therapy was made more seldom in group of С than in M group. Both drugs demonstrated metabolic neutrality, however significant lowering of glucose and uric acid levels and tendency to lowering of TC an LDLC levels was observed only in group С.
About the Authors
S. Y. MartsevichRussian Federation
N. P. Kutishenko
Russian Federation
E. V. Shilova
Russian Federation
A. D. Deev
Russian Federation
S. A. Shalnova
Russian Federation
R. G. Oganov
Russian Federation
I. A. Velishanina
Russian Federation
E. G. Volkova
Russian Federation
Yu. E. Voskanjan
Russian Federation
L. I. Gapon
Russian Federation
P. Ya. Dovgalevskij
Russian Federation
V. Ya. Ermolina
Russian Federation
E. M. Idrisova
Russian Federation
N. N. Ilov
Russian Federation
A. R. Kiseleva
Russian Federation
S Yu. Levashov
Russian Federation
V. A. Nevsorova
Russian Federation
G. I. Nechaeva
Russian Federation
T. N. Panova
Russian Federation
I. I. Reznik
Russian Federation
V. V. Skibickij
Russian Federation
L. A. Sokolova
Russian Federation
V. P. Terentev
Russian Federation
N. V. Hailo
Russian Federation
A. V. Shabalin
Russian Federation
T. V. Shnyukova
Russian Federation
V. V. Yakusevich
Russian Federation
E. N. Akulina
Russian Federation
V. A. Budanova
Russian Federation
T. S. Bondarenko
Russian Federation
V. P. Voronina
Russian Federation
I. N. Gozhaja
Russian Federation
I. I. Igricenco
Russian Federation
A. V. Drogan
Russian Federation
N. A. Dmitrieva
Russian Federation
F. M. Dyshekova
Russian Federation
A. I. Zaiceva
Russian Federation
A. N. Ikovnikova
Russian Federation
G. A. Ilicheva
Russian Federation
I. S. Irhina
Russian Federation
L. A. Kovaleva
Russian Federation
O. N. Kutkina
Russian Federation
E. A. Kudrjashev
Russian Federation
A. Z. Leonidova
Russian Federation
E. N. Loginova
Russian Federation
M. P. Marganjan
Russian Federation
O. V. Nastradin
Russian Federation
A. N. Nikitina
Russian Federation
I. N. Nikolskaja
Russian Federation
I. E. Pashinceva
Russian Federation
A. S. Petrochenko
Russian Federation
O. M. Pasnenkova
Russian Federation
E. S. Potapova
Russian Federation
A. A. Serazhim
Russian Federation
M. N. Sergeev
Russian Federation
V. V. Sidorenko
Russian Federation
V. A. Simonov
Russian Federation
D. V. Sirotenko
Russian Federation
I. N. Spanderashvili
Russian Federation
A. N. Strunina
Russian Federation
E. S. Timoschenko
Russian Federation
S. N. Tolpygina
Russian Federation
M. R. Redkina
Russian Federation
References
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Review
For citations:
Martsevich S.Y., Kutishenko N.P., Shilova E.V., Deev A.D., Shalnova S.A., Oganov R.G., Velishanina I.A., Volkova E.G., Voskanjan Yu.E., Gapon L.I., Dovgalevskij P.Ya., Ermolina V.Ya., Idrisova E.M., Ilov N.N., Kiseleva A.R., Levashov S.Yu., Nevsorova V.A., Nechaeva G.I., Panova T.N., Reznik I.I., Skibickij V.V., Sokolova L.A., Terentev V.P., Hailo N.V., Shabalin A.V., Shnyukova T.V., Yakusevich V.V., Akulina E.N., Budanova V.A., Bondarenko T.S., Voronina V.P., Gozhaja I.N., Igricenco I.I., Drogan A.V., Dmitrieva N.A., Dyshekova F.M., Zaiceva A.I., Ikovnikova A.N., Ilicheva G.A., Irhina I.S., Kovaleva L.A., Kutkina O.N., Kudrjashev E.A., Leonidova A.Z., Loginova E.N., Marganjan M.P., Nastradin O.V., Nikitina A.N., Nikolskaja I.N., Pashinceva I.E., Petrochenko A.S., Pasnenkova O.M., Potapova E.S., Serazhim A.A., Sergeev M.N., Sidorenko V.V., Simonov V.A., Sirotenko D.V., Spanderashvili I.N., Strunina A.N., Timoschenko E.S., Tolpygina S.N., Redkina M.R. COMPARISON OF THERAPIES BASED ON CARVEDILOL AND METOPROLOL IN HYPERTENSIVE PATIENTS WITH OVERWEIGHT OR OBESITY. THE FIRST RESULTS OF CAMELLIA TRIAL. Rational Pharmacotherapy in Cardiology. 2009;5(1):23-27. (In Russ.) https://doi.org/10.20996/1819-6446-2009-5-1-23-27
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